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Korea Process Technology

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High-pressure Homogenizer Applications

Application Introduction

Biological articles

Cell disruption

Applicable type of bacteria

E. coli, Yeast, Algal cells, Animal cells, Insect cells

Crushing principle

Plunger movement carries sample to a valve assembly which size can be adjusted. Samples received ultrahigh pressures squeeze, through the specific slit width. Instantaneous release of pressure to high-speed crash in the homogenizing valve. Bring about cavitation, impace effect shearing effect:So as to achieve a homogenous, emulsification, dispersion effect

Techniques

• > 99% fragmentation rate

• Built-in temperature control device:direct cooling of the working part,the temperature can be controlled at below 10 °C, the samples had no time in with high temperature residen

• PLC control: optional PLC control systems, production data monitoring, collection and output

• Modular design: The device fully modular design, can achieve SIP / CIP

• Resuspended bacterial system can be configured

• Compliance with GMP / FDA requirements





Pharmaceutical, fine chemical

Applicable type of bacteria

Pharmaceutical : Emulsifier, Suspension and other types of drugs

Fine chemical : Nanospheres, Conductive material

Techniques

Uniformity control Particle size control Temperature control Data record

( Two-level homogeneous )

• The samples could be homogenized and dispersed in first stag

• The sample would be further dispersed evenly in the second stage

• Agglomerated particles would be dispersed and PDI is less than 0.1

• Fat emulsion particle size <0.2um

• Liposome particle size<0. 1um

• Fine Chemical System Stability

Internal and external temperature control at the same time, can be adjusted within the range of 5-100 °C Monitor the whole process, in line with GMP / FDA standards

Pharmacy System





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